EXTENDED INTERVAL Dosing - Calgary Zone (Neonates Less Than 7 Days)
Exceptions to use of extended interval dosing :Renal dysfunction at baseline; consider alternate antibiotic.
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.
Any gestation, if on indomethacin, with RDS, or asphyxia or renal impairment: 5 mg/kg/DOSE q48h
5 mg/kg/DOSE q48h
5 mg/kg/DOSE q36h
5 mg/kg/DOSE q24h
EXTENDED INTERVAL Dosing - Calgary Zone (Neonates Over 7 Days of Age)
Exceptions to use of extended interval dosing: Renal dysfunction at baseline; consider alternate antibiotic.
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.
Neonates over 7 days of age: All gestations, on indomethacin or renal impairment 5 mg/kg/DOSE q36h. Less than 36 weeks: 5 mg/kg/DOSE q24h. 36 weeks or greater: 6 mg/kg/DOSE q24h.