IV-$4/d PO-$3/d

General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen, and other sites

Renal and liver function, CBC. QTc in patients with increased risk.

Tendinopathy and rupture, retinal detachment, peripheral neuropathy have been reported.

Dizziness, insomnia, rash, n/v, abdominal pain.

Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.

Strong CYP1A2 inhibitor and weak CYP3A4 inhibitor - Multiple interactions possible QTc prolongation - Increased risk with other agents that prolong QTc

AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.

Increased risk of tendon rupture with concomitant use of corticosteroids.

Monitor INR with warfarin.

Not routinely first-line therapy in children.

Antimicrobial class: Fluoroquinolone

Average serum half life: Pediatrics: 4-5 hours

Route of Elimination: 30% to 50% excreted as unchanged drug in urine via glomerular filtration and active tubular secretion; 20% to 40% excreted in feces primarily from biliary excretion; <1% excreted in bile as unchanged drug