General Information

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

  • Allergy/rash (immediate or delayed).
  • Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
  • Pseudocholelithiasis.

Calcium containing IV solutions bind to ceftriaxone forming an insoluble precipitate- avoid concurrent use with calcium contaning colutions in neonates.

IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Average serum half life: • Neonates: 1-4 days: 16 hours; 9-30 days: 9 hours

  • Pediatrics: 4.1-6.6h

Route of Elimination: unchanged in the urine (33-67%) by glomerular filtration and in feces via bile.