General Spectrum of Activity
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins
Allergy (immediate and delayed)- note potential cross-reactivity with aztreonam based on side chain
Antimicrobial class: 3rd generation Cephalosporin
Average serum half life: • neonates <23 days: 2.2-4.7 hours
Route of Elimination: by glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.