Spectrum of Activity

General Information

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Renal and liver function, CBC

Elevated liver enzymes, cytopenias, eosinophilia, phlebitis at injection site, rash/allergy, CNS toxicity, hypotension, seizures, increased SCr

Use with caution in patients with congenital or acquired arginase deficiency or other conditions where tolerance to L-Arginine may be limited.

Antimicrobial class: Monobactam

Average serum half life: Neonates:

  • <7 days, ≤2.5 kg: 5.5 to 9.9 hours
  • <7 days, >2.5 kg: 2.6 hours
  • 1 week to 1 month: 2.4 hours
  • Children 2 months to 12 years: 1.7 hours
  • Children with cystic fibrosis: 1.3 hours

Route of Elimination: 60% to 70% excreted unchanged in the urine by active tubular secretion and glomerular filtration; 12% excreted in feces