Antimicrobials
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Excellent

Dosing

General Information

  • Urinary tract infections
  • Susceptible MRSA infections
  • Stenotrophomonas infections
  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  • Gastrointestinal upset common
  • Bone marrow suppression
  • Hyperkalemia
  • Renal failure
  • Hepatitis
  • Aseptic meningitis
  • Stevens Johnson syndrome/toxic epidermal necrolysis
  • Other rashes

ACEi - Increased serum potassium level

Increases amantadine levels

Decreases cyclosporine

Methotrexate - Marrow suppression

Increases phenytoin

Increases rifampin

Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate