Aminoglycoside for synergy
Double coverage
Prosthesis Retained: 4-6 weeks IV or highly bioavailable (e.g. Ciprofloxacin when no contraindication)
Amputation: Pathogen-specific antimicrobial therapy should be given until 24-48 hours after amputation assuming all infected bone and soft tissue has been surgically removed and there is no concomitant sepsis syndrome or bacteremia