Prosthesis Retained: 2-6 weeks IV + rifampin followed by 3–6-week months oral agent + rifampin
Amputation: Pathogen-specific antimicrobial therapy should be given until 24-48 hours after amputation assuming all infected bone and soft tissue has been surgically removed and there is no concomitant sepsis syndrome or bacteremia
Prosthetic Joint Infections (PJIs)