Pathogens
Stenotrophomonas maltophilia

Stenotrophomonas maltophilia

General Information

Mild infection:

  • TMP/SMX
  • Minocycline

Moderate to severe disease:

initiate TMP/SMX and add a second agent (e.g. Minocycline, Levofloxacin) if there is a delay in clinical improvement with monotherapy

Mild infection:

  • Levofloxacin

Moderate to severe disease:

  • Combination of TMP/SMX with a second agent (e.g. Minocycline, Levofloxacin,cefiderocol)
  • Combination of ceftazidime-avibactam and aztreonam, when intolerance or inactivity of other agents are anticipated or proven

Aerobic, non-fermenting, gram-negative rod

  • May be acquired from diverse environmental sources (e.g. tap water)

  • Colonization may occur in patients with structural lung disease

  • Must distinguish colonization from clinically significant infection

Most common:

  • Bloodstream infection (usually from vascular catheter)
  • Pneumoniae (rare)
  • Urinary tract
  • Intra-abdominal infection
  • ABSSSIs
  • May require contact precautions
  • Resistance has been shown to be related to use of carbapenems