Ampicillin/Sulbactam
Metronidazole (+/- ceftriaxone)
Penicillin (if susceptible)
Piperacillin/tazobactam
Amoxicillin/Clavulanate
Anaerobic, gram-negative bacilli
Normal oral/gastrointestinal flora
Pharyngitis
Oral/dental infections
Empyema
Intra-abdominal abscess
Bacteremia
Head and neck infection including Lemierre's syndrome (septic jugular thrombophlebitis) associated with F. necrophorum
Multiple species but usually two account for most human disease: F. nucleatum and F. necrophorum
Bacteremia with F. necrophorum should prompt thorough investigation for septic thrombophlebitis (Lemierre's syndrome)