Renal function
CBC with differential
Bleeding
Seizures
Encephalopathy
Tier 2
Allergic reactions (immediate or delayed)
Bone marrow suppression
Neurotoxicity (encephalopathy, seizures)
Nephrotoxicity
Abnormal liver enzymes
Diarrhea
Headache
See Lexicomp
Zosyn
Pathogens continue to acquire increased resistance, including resistance to Zosyn. Recent research has shown better outcomes in critically ill patients when Zosyn is used in a modified (extended-infusion) dosing fashion. Additionally, pharmacodynamic/kinetic research has shown improved drug concentration: pathogen MIC ratios with this extended-infusion regimen.