Clindamycin palmitate must be hydrolyzed in the GI tract before it is active
Distribution:
Distributed in body fluids and tissues
No significant levels in CSF, even with inflamed meninges
Protein Binding: 94%
Metabolism: Biologically inactive clindamycin phosphate (intravenous formulation) is rapidly converted to active clindamycin. Clindamycin is metabolized predominantly by CYP3A4, with minor contribution by CYP3A5, to form clindamycin sulfoxide (major metabolite) and N-desmethylclindamycin (minor metabolite)
Bioavailability: Oral: ~90%
Half-Life Elimination: 3 hrs
Excretion: Urine (~10%) and feces (3.6%) as active drug and metabolites