Meningitis
Ceftriaxone

Ceftriaxone

High
N/A
$ (<$25/day)

Dosing

General Information

  • Ceftriaxone-calcium precipitation

  • Hemolytic anemia

  • Kernicterus

Calcium Salts (Intravenous):

  • May enhance the adverse/toxic effect of CefTRIAXone
  • Ceftriaxone binds to calcium forming an insoluble precipitate
  • Management: Use of ceftriaxone is contraindicated in neonates (28 days of age or younger) who require (or are expected to require) treatment with IV calcium-containing solutions
  • In older patients, flush lines with compatible fluid between administration
  • Risk D: Consider therapy modification

Rocephin

NOT recommended for S. aureus infections

  • Distribution: Widely throughout the body including gallbladder, lungs, bone, bile, CSF (higher concentrations achieved when meninges are inflamed)
  • Vd: ~6-14 L
  • Protein Binding: 85% to 95%
  • Half-Life Elimination: ~5-9 hrs
  • Excretion
    • Urine (33% to 67% as unchanged drug)
    • Feces (as inactive drug)