CSF acyclovir concentration is ~50% of plasma concentrations
Vd: Adults: 0.8 L/kg (63.6 L)
Protein Binding: 9% to 33%
Metabolism: Converted by viral enzymes to acyclovir monophosphate, and further converted to diphosphate then triphosphate (active form) by cellular enzymes
Half-Life Elimination:
Normal renal function: ~2.5 hours
ESRD: 20 hours
Hemodialysis: ~5 hours
Excretion: Urine (62% to 91% as unchanged drug and metabolite)