Antimicrobials
Levofloxacin

Levofloxacin

High
Excellent

Dosing

General Information

Pseudomonal and other gram negative infections of lungs, urinary tract, bone/joint, abdomen and other sites.

Clinical

  • Monitor QTc in patients with increased risk
  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis

Other QTc prolonging agents

Divalent cations: decreased absorption

NSAIDs: increase seizure risk

Warfarin: increased INR

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic