Preferred agent for MSSA infections.
Skin and soft tissue infection (e.g. cellulitis).
Urinary tract infections.
Endovascular infections.
Bone and joint infections.
Surgical prophylaxis.
Susceptible Staphylococcal, Streptococcal and gram negative infections.
Probenecid: prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.
Not recommended unless no other alternatives.
Antimicrobial class: 1st Generation Cephalosporin
Parameters associated with efficacy: Time dependent, associated with time free drug concentration (fT) > minimum inhibitory concentration (MIC).
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic