Previous antibiotic exposure in last 90 days (clindamycin, fluoroquinolones and penicillins/cephalosporins = highest risk)
Previous hospitalization or recent healthcare exposure (last 30 days)
Immunocompromised
Advanced age (≥ 65 years old)
Previous CDI
Acid-suppressive agents (proton pump inhibitors)
Recent GI surgery
Obesity
Discontinue antibiotics if possible
Discontinue anti-motility and pro-motility agents
Discontinue acid suppressive agents, especially proton pump inhibitors, if possible
Replace fluids and electrolytes as needed
Routine screening for C. difficile in hospitalized patients without diarrhea is NOT recommended
It is not recommended to perform repeat testing within 7 days during the same episode of diarrhea