Antimicrobials
Valganciclovir

Valganciclovir

N/A
Moderate (40 to 70%)
$3.95/450mg tablet

Spectrum of Activity

Dosing

General Information

  • CBC
  • Renal function
  • Leukopenia
  • Anemia
  • Thrombocytopenia
  • Pancytopenia
  • Birth defects
  • Increased SCr
  • Hypertension
  • Headache
  • Nausea, vomiting, diarrhea
  • Tremor
  • Absorption: Well absorbed; high-fat meal increases AUC by 30%
  • Distribution: Vdss: Ganciclovir: 0.7 L/kg; widely to all tissue including CSF and ocular tissue
  • Protein binding: Ganciclovir: 1% to 2%
  • Metabolism: Converted to ganciclovir by intestinal mucosal cells and hepatocytes
  • Bioavailability: With food: 60%
  • Half-life elimination: 4.08 hours; prolonged with renal impairment
  • Excretion: Urine (80% to 90%; primarily as ganciclovir)