Antimicrobials
Ciprofloxacin

Ciprofloxacin

Restricted

High
Good (70 to 90%)
$ (<$25/day)

General Information

  • Aortic aneurysm/aortic dissection
  • CNS effects/neuroexcitation
  • Clostridioides difficile infection
  • Glucose regulation/dysglycemia
  • Hepatotoxicity
  • Hypersensitivity reactions (immediate and delayed)
  • Myasthenia gravis
  • Peripheral neuropathy
  • Phototoxicity/photoallergy
  • QT prolongation
  • Tendinopathy/tendon rupture
  • Absorption: Well-absorbed
  • Distribution:

    • Vd: 2.1 to 2.7 L/kg
    • Tissue concentrations often exceed serum concentrations especially in kidneys, gallbladder, liver, lungs, gynecological tissue, and prostatic tissue
    • CSF concentrations: 10% of serum concentrations (noninflamed meninges), 14% to 37% (inflamed meninges)
  • Protein binding: 20%-40%

  • Metabolism: Partially hepatic

  • Bioavailability: 70%

  • Half-life elimination: 4-6 hrs

  • Excretion: Urine (35% to 70% as unchanged drug); feces (15% to 35%; <1% as unchanged drug)