With prolonged therapy, monitor hematologic, renal, and hepatic function
Tier 1
Unasyn
Ampicillin:
Sulbactam:
Distribution: Widely distributed to bile, blister, and tissue fluids; poor penetration into CSF with uninflamed meninges; higher concentrations attained with inflamed meninges
Vd: 0.25 L/kg
Protein binding: 38%
Half-life elimination: 1 to 1.3 hours
Excretion: Urine (~75% to 85% as unchanged drug) within 8 hours