Antimicrobials
Ampicillin/Sulbactam

Ampicillin/Sulbactam

Medium
N/A
$ (<$25/day)

Dosing

General Information

With prolonged therapy, monitor hematologic, renal, and hepatic function

  • Pain at injection site (with IM administration)

Ampicillin:

  • See Ampicillin monograph

Sulbactam:

  • Distribution: Widely distributed to bile, blister, and tissue fluids; poor penetration into CSF with uninflamed meninges; higher concentrations attained with inflamed meninges

  • Vd: 0.25 L/kg

  • Protein binding: 38%

  • Half-life elimination: 1 to 1.3 hours

  • Excretion: Urine (~75% to 85% as unchanged drug) within 8 hours