There is insufficient evidence for the Panel to recommend either for or against the use of high-titer COVID-19 convalescent plasma (CCP) in patients with COVID-19 who are immunocompromised. Some clinicians would consider the use of CCP in patients who, in their clinical judgment, have severe or progressive COVID-19 and an inadequate response to therapy. In these cases, clinicians should attempt to administer high-titer CCP from a vaccinated donor who recently recovered from COVID-19 likely caused by a similar SARS-CoV-2 variant as the patient.