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Gram Negative Panel

Gram Negative Panel

Note

The organisms below often represent true pathogens when isolated from blood

Gram Negative Panel Antibiotic Selection Guide

No Resistance Markers

  • Preliminary Result Recommendations: Meropenem 500mg IV q6h and Tobramycin 7mg/kg (Hartford nomogram)

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Meropenem 500mg IV q6h and Tobramycin 7mg/kg (Hartford nomogram)

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Ceftriaxone 2g IV q24h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Ceftriaxone 2g IV q24h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Ceftriaxone 2g IV q24h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Ertapenem 1g IV q24h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

No Resistance Markers

  • Preliminary Result Recommendations: Cefepime 1g IV q6h

Resistance Marker: CTX-M

  • CTX-M indicates extended spectrum beta-lactamases (ESBL)
  • Preliminary Result Recommendations: Meropenem 500mg IV q6h

Resistance Markers: KPC, IMP, OXA, NDM or VIM

  • KPC/IMP/OXA/NDM/VIM indicates carbapenem-resistant Enterobacterales (CRE)
  • Preliminary Result Recommendations: Consult ID

Preliminary Result Recommendations

  • Bactrim 5mg/kg IV q6h

Preliminary Result Recommendations

  • Ceftriaxone 2g IV q24h (q12h if suspected CNS infection)

Preliminary Result Recommendations

  • Ceftriaxone 2g IV q24h (q12h if suspected CNS infection)

Preliminary Result Recommendations

  • Ceftriaxone 2g IV q24h (q12h if suspected CNS infection)

Preliminary Result Recommendations

  • Ampicillin/sulbactam 3g IV q6h
  • May add Metronidazole 500mg IV q8h if no current anaerobic coverage

Preliminary Result Recommendations

  • Ampicillin/sulbactam 3g IV q6h
  • May add Metronidazole 500mg IV q8h if no current anaerobic coverage