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Guidelines
Initial Episode, Severe

Initial Episode, Severe

Clinical Manifestation

  • WBC ≥ 15,000 or Scr increase to ≥ 1.5
  • Due to C. difficile infection

Empiric Treatment

Fidaxomicin 200 mg PO BID
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Tier 3 Antimicrobial - Criteria for use include CDI antigen AND TOXIN positive meeting at least 1 of the following:

  • High risk for recurrence (age > 65, immunocompromised)
  • Therapeutic failure after 48 hours of vancomycin
  • Previous CDI treatment with oral vancomycin

Duration

10-14 days