Firstline - Clinical Decisions

Guidelines

Mild to Moderate PCP

Mild Cases

Pulmonary examination while the patient is at rest usually is normal
With exertion, tachypnea, tachycardia, and diffuse dry (cellophane) rales may be observed

First Line Treatment

TMP-SMX (TMP 15–20 mg and SMX 75–100 mg)/kg/day PO in 3 divided doses

OR

TMP-SMX (160 mg/800 mg or DS) two tablets PO TID

Second Line Treatment

Dapsone 100 mg PO daily

PLUS

TMP 5 mg/kg PO TID

OR

Primaquine 30 mg (base) PO daily

PLUS

Clindamycin 450 mg PO q6h or 600 mg PO q8h

OR

Atovaquone 750 mg PO twice daily with food

Duration

21 days