Firstline - Clinical Decisions

Guidelines

Severe AECOPD

Clinical Considerations

Severe exacerbation defined as:

AMS,
ICU care, OR
Need for mechanical ventilation, including NIMV

Obtain sputum culture

Empiric Treatment

Ceftriaxone 1-2g IV daily

If severe without risk factors

OR

Levofloxacin 750mg IV/PO daily

OR

Cefepime 1g IV q6h

OR

Piperacillin/tazobactam 4.5g IV q6h

Duration

5-10 days (clinical judgement)