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Guidelines
Severe

Severe

Clinical Manifestations

≥ 2 SIRS felt related to DFI:

  • Temp >100.4°F or <96.8°F
  • HR >90
  • RR >20 or PaCO₂ <32 mmHg
  • WBC >12K or <4K or ≥10% bands

Empiric Treatment

PLUS

PLUS

OR

PLUS

PLUS

OR

PLUS

Duration

Severe Skin/Soft Tissue Infection: ~2-4 weeks (shorter courses are feasible if adequate surgical intervention)

Varies by severity, clinical response, bone involvement, adequacy of blood supply and surgical intervention

  • Post-amputation/no residual infection: ~2-5 days
  • Residual soft tissue infected: 1-3 weeks
  • Residual VIABLE bone infected: ~4-6 weeks
  • No surgery OR residual DEAD non-viable bone: ≥ 3 months

Change to oral antibiotics once patient is stable

Discontinue abx once clinical signs and symptoms have resolved