Staphylococcus lugdunensis

Staphylococcus lugdunensis

General Information


  • Vancomycin

If oxacillin-susceptible:

  • Cefazolin

If oxacillin-resistant:

  • Vancomycin
  • Oxacillin (if susceptible and concern for CNS infection or infection with high inoculum)
  • Daptomycin
  • Linezolid

Gram-positive cocci in clusters, coagulase-negative

Skin flora

  • Endocarditis

  • Osteomyelitis

  • Bloodstream infections

  • Prosthetic joint infections

  • Acute bacterial skin and skin structure infections (ABSSSI)

Clinically, S. lugdunensis behaves more like Staphylococcus aureus and is more virulent than other coagulase-negative Staphylococci spp. As such, it should NOT routinely be dismissed from the blood as a contaminant