Staphylococcus aureus (MSSA)

Staphylococcus aureus (MSSA)

General Information

  • Oxacillin

  • Cefazolin

  • Vancomycin
  • Linezolid
  • Cefepime
  • Piperacillin/tazobactam or Ampicillin/sulbactam

Gram-positive cocci in clusters, coagulase-positive

Staphylococcus aureus is a ubiquitous organism that colonizes the skin/nares and can cause invasive disease

  • Purulent ABSSSIs

  • Bacteremia (Infectious Diseases consultation recommended)


  • Osteomyelitis

  • Endocarditis

  • Pneumonia

  • Meningitis (post-operative, TBIs)

  • Infection of prosthetic devices (e.g. heart valves, prosthetic joints)

Can assume Staphylococcus aureus is methicillin-susceptible if mecA/mecC is NOT detected