Pathogens
Staphylococcus aureus (MRSA)

Staphylococcus aureus (MRSA)

General Information

HA-MRSA:

  • Vancomycin

CA-MRSA:

  • TMP/SMX
  • Doxycycline

HA-MRSA:

  • Ceftaroline (restricted to ID - salvage therapy only)
  • Daptomycin
  • Linezolid

CA-MRSA:

  • Clindamycin

Gram-positive cocci in clusters, coagulase-positive

  • Can be broadly divided into health-care associated (HA) and community associated (CA)
  • HA-MRSA is associated with many hospital associated infections ranging from minor/severe skin and soft tissue infections to bloodstream infections and severe pneumonia. It also causes many device associated infection and prosthetic infections
  • CA-MRSA is associated with skin and soft tissue infections (e.g. abscesses) and necrotizing pneumonias. However, it can also cause many severe infections as with HA-MRSA

Risk factors include:

  • Recent antimicrobial use
  • Incarceration
  • IVDU
  • Central venous access
  • Post-influenza
  • Structural lung disease
  • Empyema
  • Purulent ABSSSI

  • Bacteremia (Infectious Diseases consultation recommended)

  • CLABSIs

  • Endocarditis

  • Pneumonia (necrotizing)

  • Infection of prosthetic devices (e.g. heart valves, prosthetic joints)

  • Meningitis (post-surgical, TBI)

Can assume Staphylococcus aureus is methicillin-resistant if mecA/mecC is detected