HA-MRSA:

• Daptomycin
• Linezolid
• Ceftaroline (as salvage in combination with daptomycin)

CA-MRSA:

• Clindamycin

Gram-positive cocci in clusters, coagulase-positive

• Can be broadly divided into health-care associated (HA) and community associated (CA)
• HA-MRSA is associated with many hospital associated infections ranging from minor/severe skin and soft tissue infections to bloodstream infections and severe pneumonia. It also causes many device associated infection and prosthetic infections
• CA-MRSA is associated with skin and soft tissue infections (e.g. abscesses) and necrotizing pneumonias. However, it can also cause many severe infections as with HA-MRSA

Risk factors include:

• Recent antimicrobial use
• Incarceration
• IVDU
• Central venous access
• Post-influenza
• Structural lung disease
• Empyema

• Purulent ABSSSI

• Bacteremia (Infectious Diseases consultation recommended)

• CLABSIs

• Endocarditis

• Pneumonia (necrotizing)

• Infection of prosthetic devices (e.g. heart valves, prosthetic joints)

• Meningitis (post-surgical, TBI)