Clostridium perfringens

Clostridium perfringens


General Information

Penicillin G +/- Clindamycin

  • Ampicillin/sulbactam
  • Metronidazole
  • Doxycycline
  • Piperacillin/tazobactam
  • Meropenem

Anaerobic spore forming gram positive bacilli, box-car shaped

  • Environmental (soil, water) organism as well as human/animal digestive tract

  • Associated with penetrating wounds with environmental exposure

  • Gas gangrene/Clostridial myonecrosis

  • Necrotizing skin and soft tissue infection

  • Septic abortion, tubo-ovarian abscesses, uterine gas gangrene

  • Intra-abdominal abscess

  • Fatal bacteremia with massive exotoxin-mediated hemolysis

  • Foodborne self-limited gastrointestinal illness

Surgical debridement of devitalized tissue crucial