Burkholderia cepacia complex

Burkholderia cepacia complex


General Information

  • Meropenem


  • Minocycline
  • Ceftazidime
  • Ceftazidime-avibactam (if CRE)

Aerobic, non-fermenting gram negative bacilli

  • Ubiquitous water and soil pathogen

  • Person-to-person spread has been documented, particularly among cystic fibrosis patients

  • Important pathogen in cystic fibrosis and lung transplant recipients

  • Often resistant to multiple antibiotics

  • Antimicrobial therapy should be guided by susceptibility testing whenever possible

  • Treatment options are often limited

  • Chronic infection with B. cepacia complex is associated with an accelerated decline in pulmonary function and shortened survival in cystic fibrosis