AmpC Organisms

AmpC Organisms


General Information

  • Meropenem


  • Fluoroquinolones

Gram negative organisms, usually "SPICEM" (see additional information), that have a chromosomal beta-lactamase

Most AmpC organisms are nosocomially encountered, are GI flora and are part of the Enterobacterales family

Syndromes caused by the organism that possesses AmpC (see individual organism)

  • ESBLs vs. AmpC: Most ESBLs are plasmid-encoded, whereas AmpCs are usually inducible and chromosomal
  • In the lab, AmpCs test resistant to cefoxitin and cefotetan
  • SPICEM stands for Serratia, Pseudomonas and Providencia, (Indole positive) Proteus vulgaris, Citrobacter, Enterobacter, and Morganella