Antimicrobials
Vancomycin IV

Vancomycin IV

Low
N/A
$ (<$25/day)

Spectrum of Activity

Dosing

General Information

  • Renal function

  • Therapeutic drug monitoring

  • Auditory exams with prolonged therapy

  • Nephrotoxicity

  • Drug-induced immune thrombocytopenia

  • Neutropenia

  • Agranulocytosis

  • Ototoxicity

  • Hypersensitivity reactions

  • Skin reactions, including Stevens-Johnson syndrome

  • Infusion-related reactions (histamine release- slow down infusion)

Vancocin

  • Distribution: Distributes widely in body tissue and fluids, except for CSF; Vd: 0.4 to 1 L/kg, 0.3 to 0.5 L/kg in patients who are morbidly obese
  • Protein Binding: ~55%
  • Metabolism: No apparent metabolism
  • Half-Life Elimination: Biphasic: 
    • Terminal: 4-6 hours
    • Significantly prolonged with renal impairment
  • Excretion: 
    • Primarily via glomerular filtration
    • IV: Urine (75% as unchanged drug in the first 24 hours)
  • Clearance: 1.6 to 6.2 L/hour; patients who are obese: ~6 L/hour (rarely exceeds 9 L/hour)