Antimicrobials
Valganciclovir

Valganciclovir

N/A
Moderate (40 to 70%)
$3.95/450mg tablet

Spectrum of Activity

Dosing

General Information

  • CBC

  • Renal function

  • Leukopenia

  • Anemia

  • Thrombocytopenia

  • Pancytopenia

  • Birth defects

  • Increased SCr

  • Hypertension

  • Headache

  • Nausea, vomiting, diarrhea

  • Tremor

  • Absorption: 
    • Well absorbed
    • High-fat meal increases AUC by 30%
  • Distribution: Vdss: Ganciclovir: 0.7 L/kg; widely to all tissue including CSF and ocular tissue
  • Protein Binding: Ganciclovir: 1% to 2%
  • Metabolism: Converted to ganciclovir by intestinal mucosal cells and hepatocytes
  • Bioavailability: With food: 60%
  • Half-Life Elimination: 
    • 4.08 hours
    • Prolonged with renal impairment
  • Excretion: Urine (80% to 90%; primarily as ganciclovir)