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Antimicrobials
Tobramycin

Tobramycin

Low
N/A
$ (<$25/day)

Dosing

General Information

  • Renal function

  • Auditory exam with prolonged therapy

  • Therapeutic drug monitoring

  • Nephrotoxicity

  • Ototoxicity

  • Neuromuscular blockade (avoid in patients with myasthenia gravis)

  • Distribution: 
    • Distributes to extracellular fluid, including serum, abscesses, ascitic, pericardial, pleural, synovial, lymphatic, and peritoneal fluids
    • Poor penetration into CSF, eye, bone, prostate
    • Vd 0.2-0.3L/kg
  • Protein Binding: <30%
  • Half-Life Elimination: 2-3 hours
  • Excretion: Urine, 90-95% within 24 hours