Antimicrobials
Tigecycline (NF)

Tigecycline (NF)

Restricted

Low
N/A
$$ ($26-100/day)

Spectrum of Activity

General Information

  • LFTs

  • Coagulation parameters

  • Increased mortality

  • Diarrhea

  • Nausea

  • Vomiting

  • Coagulopathy

  • Increased LFTs

  • Pancreatitis

Preferred tetracycline-derivative: Eravacycline. Call MD to recommend changing therapy.

Non-formulary

  • Distribution: 
    • Vd: 7-9 L/kg
    • Extensive tissue distribution; distributes into gallbladder, lung, and colon
  • Protein Binding: 71% to 89%
  • Metabolism: Hepatic, via glucuronidation, N-acetylation, and epimerization to several metabolites, each <10% of the dose
  • Half-Life Elimination:
    • Single dose: 27 hours
    • Multiple doses: 42 hours; increased by 23% in moderate hepatic impairment and 43% in severe hepatic impairment
  • Excretion: 
    • Feces (59%, primarily as unchanged drug)
    • Urine (33%, with 22% of the total dose as unchanged drug)
  • Clearance: Reduced by 25% in patient with moderate hepatic impairment and 55% in severe hepatic impairment