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Antimicrobials
Rifampin

Rifampin

Low
Excellent (90 to 100%)
IV: $3.18/dose; PO: $0.55/dose

Spectrum of Activity

General Spectrum of Activity
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Dosing

General Information

  • LFTs

  • CBC

  • Drug Interactions

  • Fluid discoloration

  • Hepatotoxicity

  • Hematologic effects, including decreased hemoglobin, DIC, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia

  • Significant drug-drug interaction potential

  • Discoloration of bodily fluids

  • Hypersensitivity reactions

See Lexicomp; significant drug-drug interactions

  • Duration: ≤24 hours
  • Absorption: 
    • Well absorbed
    • Food may delay or slightly reduce peak
  • Distribution:
    • Highly lipophilic
    • Crosses blood-brain barrier well
  • Protein Binding: 80%
  • Metabolism: 
    • Hepatic
    • Undergoes enterohepatic recirculation
  • Half-Life Elimination: 2-3 hours at steady-state
  • Time to Peak, Serum: ~2 hours
  • Excretion: Feces (60% to 65%) and urine (~30%) as unchanged drug