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Antimicrobials
Polymyxin B

Polymyxin B

Restricted

Low
N/A
$$ ($25-100/day)

Spectrum of Activity

General Spectrum of Activity
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General Information

  • Renal function

  • Mental status

  • Nephrotoxicity

  • Thrombophlebitis

  • Neurotoxicity (including blurred vision)

  • Neuromuscular blockade

  • Absorption: Not absorbed from GI tract
  • Distribution:
    • Central Vd: ~0.09 L/kg
    • Peripheral Vd: 0.33 L/kg
  • Protein Binding: ~60%
  • Half-Life Elimination: 6 hours, increased with reduced renal function
  • Excretion: Urine (<1% as unchanged drug within first 12 hours; as therapy continues, up to 60% as unchanged drug in the urine)