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Antimicrobials
Piperacillin/Tazobactam

Piperacillin/Tazobactam

Medium
N/A
$ (<$25/day)

Dosing

General Information

  • Renal function

  • CBC with differential

  • Bleeding

  • Seizures

  • Encephalopathy

  • Allergic reactions (immediate or delayed)

  • Bone marrow suppression

  • Neurotoxicity (encephalopathy, seizures)

  • Nephrotoxicity

  • Abnormal liver enzymes

  • Diarrhea

  • Headache

  • Distribution: 0.243L/kg
  • Protein Binding: 
    • Piperacillin: 26-33%
    • Tazobactam: 32%
  • Half-Life: 0.7-1.2 hours
  • Excretion: Clearance of both piperacillin and tazobactam are directly proportional to renal function
    • Piperacillin: 
      • Urine (68% as unchanged drug)
      • Feces (10% to 20%)
    • Tazobactam: Urine (80% as unchanged drug; remainder as inactive metabolite)