Antimicrobials
Penicillin G

Penicillin G

Medium
N/A
$$ ($26-100/day)

Spectrum of Activity

Dosing

General Information

  • Sodium

  • Potassium

  • Renal function

  • Seizure activity

  • Allergic reactions (immediate or delayed)

  • Seizures

  • Jarisch-Herxheimer reaction

  • Acute interstitial nephritis

Pfizerpen

Interchange to ampicillin for L&D orders. Preferred for neurosyphilis - do not interchange.

  • Distribution: Poor penetration across blood-brain barrier, despite inflamed meninges
  • Half-Life Elimination: 31-50 minutes
  • Time to Peak, Serum: IV: Immediately after infusion
  • Excretion: Urine (58% to 85% as unchanged drug)