Antimicrobials
Oxacillin

Oxacillin

Medium
N/A
$$ ($26-100/day)

Spectrum of Activity

Dosing

General Information

  • Signs/symptoms of anaphylaxis during first dose

  • Renal function

  • LFTs

  • Hepatotoxicity

  • Acute interstitial nephritis or renal tubular disease

  • Eosinophilia

  • Distribution: 
    • Into bile, pleural fluids
    • Insignificant concentrations in CSF and aqueous humor
  • Protein Binding: ~94% (mainly albumin)
  • Metabolism: Hepatic
  • Half-Life Elimination:
    • 20-30 minutes
    • Prolonged with renal impairment
  • Time to Peak, Aerum:
    • IM: 30 minutes
    • IV: 5 minutes
  • Excretion: Urine and bile (unchanged drug)