Antimicrobials
Minocycline

Minocycline

Restricted

Low
Excellent (90 to 100%)
PO: $1.74/dose; IV: $175.34/dose

Spectrum of Activity

General Information

IV Formulation: Tier 4

Increased LFTs

  • Absorption: Oral: Well absorbed
  • Distribution: 
    • Widely distributed to most body fluids, bile, and tissues
    • Poor CNS penetration; deposits in fat for extended periods
    • Vd: 0.14 to 0.7 L/kg
  • Protein Binding: 55% to 96%
  • Metabolism: Hepatic to inactive metabolites
  • Bioavailability: 90% to 100%
  • Half-Life Elimination: 
    • IV: 
      • 15-23 hours
      • 11-16 hours (hepatic impairment)
      • 18 to 69 hours (renal impairment)
    • Oral: 16 hours (range: 11-17 hours)
  • Excretion: 
    • Urine 5% to 12% excreted unchanged
    • Feces (20% to 34%)