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Antimicrobials
Micafungin

Micafungin

Restricted

N/A
N/A
$$$ ($101-200/day)

Spectrum of Activity

General Spectrum of Activity
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General Information

  • LFTs

  • Phlebitis

  • Vomiting

  • Diarrhea

  • CBC

  • Increased liver enzymes

  • Vomiting, diarrhea

  • Phlebitis

  • Anemia

Mycamine

  • Distribution: 
    • Distributes into lung, liver, and spleen; minimally to CNS and eyes
    • Vd: 0.39 +/- 0.11 L/kg
  • Protein Binding: >99% to albumin
  • Metabolism: 
    • Hepatic to M-1, catechol form by arylsulfatase; further metabolized to M-2, methoxy form by catechol-O-methyltransferase
    • Hydroxylation to M-5 by CYP3A
  • Half-life: 11-21 hours
  • Excretion: 
    • Primarily feces (71%)
    • Urine (<1%, unchanged)
  • Clearance: ~0.3 mL/minute/kg