Antimicrobials
Meropenem/Vaborbactam

Meropenem/Vaborbactam

Restricted

High
N/A
>$500/day

Spectrum of Activity

General Information

KPC-producing carbapenem-resistant infections

  • Renal function

  • CNS toxicity (altered mental status, delirium, seizures)

  • CNS toxicity

  • Delayed or immediate hypersensitivity reactions

Vabomere

  • Distribution: Vd:
    • Meropenem: 20.2 L
    • Vaborbactam: 18.6 L
  • Protein Binding:
    • Meropenem: ~2%
    • Vaborbactam: ~33%
  • Metabolism:
    • Meropenem: Hydrolysis of beta-lactam bond to open lactam form (minor)
    • Vaborbactam: Not metabolized
  • Half-Life Elimination:
    • Meropenem: 1.22 hours
    • Vaborbactam: 1.68 hours
  • Excretion:
    • Meropenem:
      • Urine (40% to 60% [unchanged]; 22% inactive hydrolysis product)
      • Feces (~2%)
    • Vaborbactam: Urine (75% to 95% [unchanged])