Antimicrobials
Levofloxacin

Levofloxacin

High
Excellent
PO: $0.24/dose; IV: $2.45/dose

Spectrum of Activity

General Information

  • QTc

  • Renal function

  • LFTs

  • Signs/symptoms of tendinopathy or peripheral neuropathy

  • Disordered glucose regulation

  • Altered mental status

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

  • Aortic aneurysm/dissection

  • Hepatotoxicity

  • Phototoxicity

Levaquin

  • Absorption: 
    • Rapid and complete
    • Levofloxacin oral tablet and solution formulations are bioequivalent
  • Distribution: 
    • Widely distributed in the body, including blister fluid, skin tissue, macrophages, prostate, and lung tissue
    • CSF concentrations ~15% of serum concentrations
    • Vd: 1.27 L/kg
  • Protein Binding: 
    • ~24% to 38%
    • Primarily to albumin
  • Metabolism: Minimally hepatic
  • Bioavailability: ~99%
  • Half-Life Elimination: ~6-8 hours
  • Time to Peak, Serum: Oral: 1-2 hours
  • Excretion: 
    • Urine (~87% as unchanged drug, <5% as metabolites)
    • Feces (<4%)