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Antimicrobials
Letermovir

Letermovir

Restricted

None
Excellent (90 to 100%)
$6,000+ for #28, 480mg tablets

Spectrum of Activity

General Spectrum of Activity
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General Information

CMV prophylaxis

CMV treatment

  • CMV reactivation

  • SCr (for patients with CrCl <50 mL on IV formulation)

  • Peripheral edema

  • Headache

  • Fatigue

  • Nausea

  • Diarrhea

  • Vomiting

  • Abdominal pain

  • Cough

  • Decreased platelet count

Prevymis

  • Distribution (IV): 45.5 L
  • Protein Binding: 99%
  • Metabolism: Hepatic via UGT1A1/1A3 (minor)
  • Half-Life Elimination: 12 hours
  • Time to Peak: 1.5-3 hours
  • Excretion:
    • Feces: 93% (70% as unchanged drug)
    • Urine: <2%