Antimicrobials
Imipenem/cilastatin

Imipenem/cilastatin

Restricted

High
N/A
$$ ($26-100/day)

Spectrum of Activity

General Information

  • Renal function

  • Hepatic function

  • CBC

  • Seizures

  • Increased LFTs

Primaxin

  • Protein Binding: 
    • Imipenem: ~20%
    • Cilastatin: ~40%
  • Metabolism: 
    • Imipenem is metabolized in the kidney by dehydropeptidase I
    • Cilastatin prevents imipenem metabolism by this enzyme
  • Half-Life Elimination: 
    • Prolonged with renal impairment
    • Adults: ~60 minutes
  • Excretion: Urine (~70% as unchanged drug)