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Antimicrobials
Gentamicin

Gentamicin

Low
N/A
$ (<$25/day)

Dosing

General Information

  • Serum creatinine

  • Therapeutic drug monitoring

  • Audiology exams (if use prolonged)

  • Nephrotoxicity

  • Vestibulocochlear toxicity

  • Contraindicated in patients with myasthenia gravis

  • Absorption: Rapid and complete
  • Distribution: 
    • Primarily into extracellular fluid (highly hydrophilic); high concentration in the renal cortex
    • Minimal penetration to CSF and ocular tissues via IV route
    • Vd: 0.2 to 0.3 L/kg
  • Protein Binding: <30%
  • Half-Life Elimination: 
    • ~2 hours
    • Renal failure: mean: 41 ± 24 hours
  • Excretion: Urine (≥70% as unchanged drug)
  • Clearance: Directly related to renal function: 0.06 L/hour/kg