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Antimicrobials
Fluconazole

Fluconazole

None
Excellent (90 to 100%)
<$25 per day

Spectrum of Activity

General Spectrum of Activity
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Dosing

General Information

  • Monitor QTc

  • LFTs

  • Renal function

  • Drug/drug interactions (though to a lesser extent than many azoles)

  • QTc prolongation

  • Liver enzyme abnormalities

  • Drug/drug interactions

  • Alopecia

  • Headache

Diflucan

  • Absorption: 
    • Well absorbed
    • Food does not affect extent of absorption
  • Distribution (Vd):
    • ~0.6 L/kg; good penetration into CSF, eye, peritoneal fluid, sputum, skin, and urine
    • CSF:blood level ratio: Normal meninges: 50% to 90%; Inflamed meninges: ~80%
  • Plasma Protein Binding: 11% to 12%
  • Bioavailability: Oral: >90%
  • Half-Life Elimination: 
    • Normal renal function: ~30 hours (range: 20 to 50 hours)
    • Elderly: 46.2 hours
  • Time to Peak, Serum: 1 to 2 hours
  • Excretion: Urine (80% as unchanged drug)