Antimicrobials
Ertapenem

Ertapenem

Restricted

High
N/A
$$ ($26-$100/day)

Spectrum of Activity

General Information

Valproate Products:

  • Carbapenems may decrease the serum concentration of Valproate Products
  • Management: Concurrent use of carbapenem antibiotics with valproic acid is generally not recommended
    • Alternative antimicrobial agents should be considered, but if a concurrent carbapenem is necessary, consider additional anti-seizure medication
  • Distribution: Vd:~0.12 L/kg
  • Protein Binding: 85%-95%
  • Metabolism: Non-CYP-mediated hydrolysis to inactive metabolite
  • Half-Life Elimination: ~4 hours
  • Excretion
    • Urine (80% as unchanged drug and metabolite)
    • Feces (10%)